Topic: A Study on Mechanism of Action of Ubiquitin-Like Proteins FAT10 Against Myocardial Infarction

Speaker: Dr. WAN Rong

Time: 12:30 on March 30, 2023

Location: Conference Room, Institute for Advanced Studies (B1210, Architectural Building)

[Abstract] As the most common fatal cardiovascular disease, Myocardial infarction （MI）has seen an increasingly higher incidence and mortality rate. Ubiquitin-like proteins （UBLS）is a kind of small molecular protein that shares certain homologous sequence or functions with ubiquitin. FAT10, among all UBLS, is the only one that can directly mediate protea some-associated degradation. Present studies show FAT10 has played a vital role in various cell activities including cycle, apoptosis and tumorigenesis. Our team is the first to report FAT10’s expression in heart tissue. The action of FAT10 against cardiovascular diseases, however, is rarely reported. This report puts its focus on the study on the mechanism of action of FAT10 during the whole pathological process of MI.

[About the Speaker] WAN Rong, PharmD. of Nanjing Medical University, is an associate researcher of NCU Second Affiliated Hospital and supervisor of postgraduate student, who won the title of Ganjiang Young Scholar of NCU “215 Talent Project”. WAN Rong is the standing member of Jiangxi Provincial Pharmacological Society, a member of the first session and the standing member of the second session of Youth Board of Cardiovascular Pharmacological Committee of Chinese Pharmacological Society. Dr. WAN has published 40 SCI papers, among which 16 boast Dr. WAN as their first author and corresponding author. Dr. WAN has led 3 projects supported by the National Natural Science Foundation of China, and 6 projects supported by the Natural Science Foundation of Jiangxi Province.