Zhang Jin Scientific Research Team Obtaining New Research Results in Cardiovascular Drug Target Structure

Recently, Professor Zhang Jin of School of Basic Medical Sciences of Nanchang University cooperated with Medical College of Harvard University and The Howard Hughes Medical Institute to issue a research thesis titled Structure of full-length human TRPM4 in the academic journal of PNAS, showing length structure of human TRPM4 ion channel 3.7 Å resolution ratio. The corresponding authors are Professor Zhang Jin of Basic Medical Sciences of Nanchang University and Professor David Clapham of Medical College of Harvard University.

The ion channel is an important drug target, and many drugs in sale have direct or indirect effects on the ion channel, and targeted ion channel drugs account for 17% of drug sales amount of the world. TRPM4 is a non-specificity positive ion channel activated by Ca2+, and it has expressions in many cells of cardiovascular system, such as cardiac cell for conduction path, smooth muscle cells of artery and vein, which is an important drug target for treating hypertension and arrhythmia. The structural analysis on length structure of human TRPM4 has an important meaning on understanding TRPM4-related cardiovascular disease pathogenesis and physiological function, providing theory guidance and structural basis for developing targeted TRPM4 cardiovascular drugs.

   Professor Zhang Jin, is the national “Youth Thousands Persons”, a post-doctoral of Harvard University, now a specially-appointed professor of School of Basic Medical Sciences and Biomedicine Research Institute of Nanchang University, and a doctoral supervisor.     He undertakes researches on structure and function of drug targets of cardiovascular disease. Through x-ray crystallography and unimolecule electron cryomicroscopy, he applies multidisciplinary methods including medicinal chemistry, pharmacology and electrophysiology to study and analyze three-dimensional structure of cardiovascular disease-related membrane protein (including G-protein-coupled receptors and ion channel), and develops new cardiovascular drugs on this structure. Recent years, he successively issued theses on Nature (2 theses), PNAS, Proteins (2 theses) as the first author or the corresponding author; and issued several theses on international major journals including Nature Communications, Developmental Cell, Cell Cycle.

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